Yang Xia, Ph.D.

Distinguished Professor

Professor of Physics

Fellow of APS (American Physical Society)

Fellow of ISMRM (International Society for Magnetic Resonance in Medicine)



Department of Physics, Oakland University


276 Hannah Hall

244 Meadow Brook Road, Rochester MI 48309-4451

 

Office Phone: (248) 370-3420


Lab Phones: (248) 370-2403 (NMR Lab), (248) 370-3402 (All Labs except the NMR Lab)

-3861 (Big Room), -3862 (PLM Lab), -4873 (FTIRI Lab), -4259 (Student Office)

 

Fax: (248) 370-3408

 

Email: xia@oakland.edu

 

Web: http://www.oakland.edu/~xia/

(https://files.oakland.edu/users/xia/web/)

Profile

Presentations

Laboratory

Teaching

Gallery

Personal

ICMRM Beauty Contest

Open Lab Positions



I am a Professor of Physics in the Physics Department at Oakland University. I teach undergraduate and graduate courses in physics. My major research project studies the degradation of articular cartilage, which leads to osteoarthritis (the #1 cause of disability in human).

We use multidisciplinary microscopic imaging approach to study different aspects of cartilage degradation. We are truly unique in high-resolution imaging research, since we have six complementary microscopic imaging systems in our lab, with spatial resolutions ranging from a fraction of µm to tens of µm. We know each instrument thoroughly and have developed quantitative protocols on each system. My cartilage research has been continuously supported by four 5-year R01 grants from the National Institutes of Health (NIH) since January 1999. My current research funding from NIH goes till March 2022.

On March 15, 2016, I delivered an edited book to the Royal Society of Chemistry (Cambridge, UK). The title of the book is “Biophysics and Biochemistry of Cartilage by NMR and MRI”. This is a unique book providing a contemporary snapshot of the roles NMR and MRI play in the current understanding of the biophysics and biochemistry of articular cartilage. As a treatise on cartilage research, it is the first book of its kind. This book has been published on Nov 16, 2016 (ISBN 978-1-78262-133-1). Here is the cover of the book.

Please check the link "Laboratory" for more information about my lab.
These external links document my research:
     NIH BioSketch at SciENcv:        http://www.ncbi.nlm.nih.gov/myncbi/xia_ou/cv/56208/
     Google Scholar:      https://scholar.google.com/citations?hl=en&user=yQKkkJwAAAAJ



Research Interests and Tools

  • Microscopic Imaging and Multi-disciplinary Correlation
    • NMR Microscopy (µMRI) – imaging molecular dynamics with resolution as fine as tens microns
    • Polarized Light Microscopy (PLM) - calculation of collagen matrix's retardation and angle
    • Electron Microscopy (TEM) - quantification of graphical details in images
    • Fourier Transform Infrared Imaging (FTIRI) - tissue anisotropy and molecular quantitation
    • Microscopic Computer Tomography (µCT) - the interface between soft (cartilage) and hard (bone) tissues
    • Biomechanics and Optical Imaging - 2D visualization of the strain distribution in soft tissue
  • Quantitative Mapping of Physical Parameters in Biological Systems
    • Velocity, self-diffusion, relaxation, anisotropy, chemical shift
    • Optical organization (retardation), fiber orientation (birefringence), infrared dichroism
  • Image Analysis and Processing
    • Binary data translation in multi-dimensional format (complex binary images)
  • Applications in Complex Systems
    • Articular cartilage, bone, and osteoarthritis (OA)
    • Eye and cataract, spider and dragline silk, vascular flows in plants
    • Polymer tube flows (eg, tubeless siphon or Fano flow)

Initial setup: January 4, 1999 (while others are digging themselves out of the Blizzard 99)

Last minor update (at https://files.oakland.edu/users/xia/web/): June 14, 2019